Author

Zhen Qi

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Open access Sep 2026

Therapeutic Potential of iPSC-Derived TH⁺/FOXA2⁺ Neuronal Extracellular Vesicles in Parkinson’s Disease Revealed by Organoid and Rodent Models

Background Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (DA) neurons and aberrant α-synuclein (α-syn) aggregation, yet disease-modifying therapies that simultaneously retard neurodegeneration and foster regeneration remain lacking. Methods In this study, we isolated extrace...

Zhen Qi, Xiao-Wen Li, Xiao Jin et al. · bioRxiv · 0 citations

Review Open access Jul 2026

Extracellular vesicles in heart failure: bridging pathogenic insights, diagnostic utility, and therapeutic applications

Heart failure (HF), the terminal stage of most cardiovascular diseases, remains a major global health burden with limited therapeutic options that do not fully achieve myocardial repair or functional recovery. Extracellular vesicles (EVs), nanoscale membrane-bound particles released by cells, have been increasingly rec...

Tingting Li, Jin Yang, Xinyue Ding et al. · Frontiers in Pharmacology · 0 citations