Open access
Aug 2026
Integrative transcriptomic and experimental analysis identifies GREM1 as a pro-metastatic mediator in lung adenocarcinoma
Mechanistically, GREM1 interacts with BMP2 and induces epithelial–mesenchymal transition and glycolysis via the TGF-β signaling pathway, thereby promoting LUAD progression and metastasis, and emerges as both a metastasis driver and therapeutic target.
Zhen-Qing Li, Hui-Rong Huang, Ke-Rong Zhai et al.
· Journal of Translational Med... · 0 citations