Extracerebral microvascular burden links to dementia risk and brain structural changes: Evidence from a large‐scale cohort study
The contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.
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The contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.
This large-scale proteome-wide study not only reveals significant proteomic changes preceding SLD diagnosis but also establishes GDF15 as both a promising preclinical biomarker and opening new avenues for early intervention in at-risk individuals.
The findings delineate etiologically and clinically distinct MASLD subtypes, reveal protein-mediated pathways to systemic diseases, and inform biologically guided prevention strategies.
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