Sep 2026
Exosomal METTL16 from mesenchymal stem cells promotes malignant progression and M2 macrophage polarization in acute myeloid leukemia via IGF2BP2-dependent GPX1 m6A modification.
Exosomal METTL16 from AML-MSCs plays a crucial role in promoting leukemic cell survival and M2 polarization, and targeting this axis may provide a potential theoretical foundation to reverse M2 macrophage polarization and inhibit AML progression.
Zhen Shang, Mi Zhou, Si-Jia Yan et al.
· Biochimica et Biophysica Act... · 0 citations