This study investigated the lung-targeting characteristics, dose- and time-dependent effects, and safety of a novel engineered adeno-associated virus (AAV) vector, AAV-LungM3. In vitro, mouse primary lung organoids were transduced with AAV-LungM3 at doses of 103, 104, and 105 vector genomes (vg)/cell, and transduction...
Heng-Hai Nie, Juan Du, Xi-Feng Feng et al.· Journal of Visualized Experi...· 0 citations
Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological dysfunction. This review provides a comprehensive analysis of TRM biology in inflammation and cancer. We first delineate the het...
Si-Yuan Huang, Jiang-Bo Fan, Wen-Yi Liu et al.· MedComm· 0 citations
MSM alleviates lethal MRSA infection by enhancing macrophage phagocytosis and promoting NO production to eliminate intracellular bacteria, position MSM as a promising therapeutic agent against drug-resistant bacterial infections, offering a novel strategy for managing sepsis.
Hao-Ru Liu, Wan-Qi Tang, Hongsheng Zheng et al.· Life Science· 0 citations
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