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Open access Aug 2026

Polyphyllin I Orchestrates Autophagy to Reprogram the Tumour Immune Microenvironment and Abrogate Cisplatin Resistance in Non-Small Cell Lung Cancer.

OBJECTIVE This study aims to elucidate the molecular mechanisms by which Polyphyllin I (PPI), a potent steroidal saponin, attenuates non-small cell lung cancer (NSCLC) progression via mechanistic reprogramming of an autophagy-dependent immunogenic response. METHODS Integrated in vitro (A549, H460) and in vivo (LLC xe...

Zongxu Liu, Yanping Li, Shumin Li et al. · 0 citations
Review Open access Aug 2026

Emerging targeted therapies for primary immune thrombocytopenia: novel agents, combination strategies, and future directions

This article analyses recent therapeutic trials with Bruton’s tyrosine kinase inhibitors, splenic tyrosine kinase inhibitors, and neonatal Fc receptor antagonists, demonstrating an improvement in platelet counts and patients’ quality of life.

Zhen Wang, Wu-Xia Yang, Nuo Xu et al. · 0 citations

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