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Open access Sep 2026

Trimethylamine N-oxide promotes lymphoid differentiation of hematopoietic stem and progenitor cells.

BACKGROUND Persistent lymphopenia represents a clinically relevant adverse effect associated with radiotherapy, surgery and infection and is linked to unfavorable clinical outcomes. Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite generated from dietary choline and L-carnitine, has emerged as a potent...

Min Zhang, Han-Yi Mei, Xin-Yu Bai et al. · 0 citations
Open access Aug 2026

Identification and validation of shared inflammatory transcriptomic signatures across multiple tissues in severe acute pancreatitis

Severe acute pancreatitis (SAP) is frequently accompanied by systemic inflammatory responses and multi-organ injury; however, the shared transcriptomic programs underlying its systemic progression remain incompletely defined. This study aimed to identify conserved inflammatory signatures across SAP-affected tissues u...

Xia Xu, Zhen Weng, Xing Wei et al. · 0 citations

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