Cardiometabolic vulnerability and incident frailty across three aging cohorts: a multicohort longitudinal study of HRS, ELSA, and CHARLS
Cardiometabolic dysfunction is linked to frailty, but whether a fixed-weight biomarker score developed for one functional aging outcome retains an association with incident frailty without re-estimating its weights is unknown. We evaluated the systolic blood pressure–HDL–A1c–CRP (SHAC) index, originally developed...