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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Zhen-Xing Wang

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Review Open access Sep 2026

Dual roles of DDR1 in stromal remodeling and immune escape: a regulator of the tumor immune microenvironment

The discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase that orchestrates multiple cellular processes and remodels the tumor immune microenvironment (TIME). Notably, DDR1 promotes immune exclusion predominantly through its extracellular domain, which regulates collagen fiber alignment to...

Xiao-Xiao Xu, Zhen-Xing Wang · 0 citations

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