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Open access Sep 2026

PERM1 Gene Therapy Prevents Pressure Overload-induced Heart Failure Through a Sarcomere-Mitochondria Energetic Microdomain

Heart failure with reduced ejection fraction (HFrEF) remains a major cause of morbidity and mortality worldwide, characterized by impaired contractile function and mitochondrial dysfunction, yet therapies that simultaneously restore cardiac energetics and mechanical performance remain limited. Here, we show that adeno-...

Karthi Sreedevi, A. Doku, Alexey V. Zaitsev et al. · 0 citations
Open access Sep 2026

Targeting Mitochondrial Dysfunction with Mdivi-1 Confers Therapeutic Protection in Cell Culture and Mouse Models of Mustard Keratopathy

Mustard keratopathy, caused by exposure of the cornea to sulfur or nitrogen mustard vesicants, chemical warfare agents, can lead to severe and often irreversible vision loss. Despite considerable efforts to develop medical countermeasures, including anti-inflammatory, antioxidant, anti-fibrotic, and anti-angiogenic the...

Arpan G. Mazumder, Evan Magarychoff, Hamid Alemi et al. · 0 citations

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