Author

Zhen-Yu Lin

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Open access Oct 2026

Representation learning of somatic missense mutation landscapes across cancer types

Somatic missense mutations are pervasive in cancer genomes, yet existing studies have largely compressed them into mutation burden, mutation signatures, or driver gene annotations. Such representations obscure mutation-specific context and higher-order dependencies, leaving the latent biological structure of somatic mu...

Ze-Lin Wang, Min-Fang Cai, Zhe-Wen Li et al. · bioRxiv · 0 citations

Review Oct 2026

Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy versus standard of care for locally advanced rectal cancer (UNION): a prespecified interim analysis of a multicentre, open-label, randomised, phase 3 trial.

BACKGROUND To our knowledge, UNION is the first phase 3 trial to assess a neoadjuvant strategy incorporating radiotherapy, immunotherapy, and chemotherapy compared with standard care in patients with locally advanced rectal cancer, which reported positive results for the primary endpoint (blinded independent review com...

Kai-Xiong Tao, Zhen-Yu Lin, Peng Zhang et al. · The Lancet Oncology · 0 citations