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Author

Zhen-Yu Wang

2 papers indexed here

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Sep 2026

Discovery of a Broad-Spectrum Antiviral Compound against Porcine Reproductive and Respiratory Syndrome Virus

Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses to the swine industry, while vaccine-based control remains challenges. The study performed structure−activity relationship (SAR)-guided optimization of tylvalosin, yielding 42 novel derivatives. Compound V-28 exhibited the...

Xiao-Pei Yang, Ru-Meng Ma, Ying-Hong Long et al. · 0 citations
Open access Sep 2026

Outer membrane vesicles secreted by avian pathogenic Escherichia coli promote intracellular survival in macrophages and systemic infection by regulating mitophagy through the MSTRG.11745.1/gga-miR-15b-5p/TNFAIP3 axis

Avian pathogenic Escherichia coli (APEC) is a major extraintestinal pathogen responsible for severe systemic infections in poultry. It evades the immune system and establishes persistent infection by hijacking macrophages as its primary site of intracellular survival. During the pathogenic process, outer membrane vesic...

Jia-Yin Gao, Zhe Li, Tong-Tong Cui et al. · 0 citations

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