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Author

Zhen Zhang

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Review Open access Aug 2026

Mechanical properties of the tumor microenvironment: drivers of immunotherapy resistance in solid tumors

The limited efficacy of immunotherapy in solid tumors is increasingly recognized to reflect not only molecular and cellular immune suppression, but also profound mechanical abnormalities within the tumor microenvironment (TME). Emerging evidence indicates that extracellular matrix (ECM) stiffening and architectural rem...

Zhen Zhang, Tian-Hao Deng, Wanshuang Zhou et al. · 0 citations

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