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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zhen-Zhen Guo

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Jul 2026

Circular Bivalent Aptamer Chimeras Leveraging LDLR-Mediated Lysosomal Shuttling for Targeted Protein Degradation.

A lysosome-targeting degradation platform based on circular bivalent aptamer chimeras (CBACs), which simultaneously engage the lysosomal shuttle receptor LDLR and target membrane proteins, which demonstrates efficient and selective degradation of two cancer-therapeutically relevant membrane proteins in multiple cancer cells, leading to apoptosis and reduced invasion and migration.

Ningyi Li, Zhen-Zhen Guo, Ruirui Zhang et al. · 0 citations

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