Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the technology’s utility in studying underl...
Zhen-Chao Tang, Fang Wang, Fan Yang et al.· Nature Communications· 2 citations
T-cell receptor (TCR) recognition of antigenic peptides presented by human leukocyte antigen (HLA) molecules underpins adaptive immunity and T cell-based immunotherapy. However, the scarcity of complete interaction data and TCR cross-reactivity challenge robust prediction. Here, we present UpTCR, a unified progressiv...
Tian-Xu Lv, Yang Xiao, Li Chen et al.· Nature Communications· 0 citations
Biomolecular binder design for peptides and antibodies requires generating diverse candidates that satisfy stringent three-dimensional geometric constraints while enabling affinity-oriented exploration under strong structural priors. In current generative models, the effective search space for structurally feasible bin...
Zhihua Tian, Jia-Le Zhou, Ru-Bo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
Semantics-Preserving Exploratory Sampling (SPES), which integrates Graph Laplacian Spectral Noise to respect chain connectivity and Conditional Freedom Modulation to dynamically balance exploration with fidelity, enables diversity-enhanced generation without sacrificing geometric validity under the reported structural...
Zhihua Tian, Jiale Zhou, Rubo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
By combining protein language model embeddings with topology-adaptive geometric reasoning, DiConSite offers a reusable framework for residue-level protein interaction analysis and achieves consistently strong and often best-performing results, while improving robustness to structural uncertainty and cross-modal variati...
Shou-Zhi Chen, Zhen-Chao Tang, Lin-Lin You et al.· IEEE Transactions on Pattern...· 1 citation
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
