ABSTRACT Cellular pyroptosis, a pro‐inflammatory form of programmed cell death, emerges as a promising strategy for cancer immunotherapy. However, gene methylation hampers the expression of gasdermin E (GSDME), a pivotal protein in the caspase‐3‐mediated pyroptosis pathway, across numerous malignancies, including tripl...
Yang Hong, Haitao Wu, Weitao Wang et al.· Advancement of science· 0 citations
An intelligent nanoplatform-GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.)-based on reversible addition-fragmentation chain transfer (RAFT) polymerization technology is constructed, establishing a valuable technical framework for the development of multifunctional and stimuli-responsive nanomedicines.
Huai-Bin Yu, Zhuo-Rong Miao, Meng Wang et al.· ACS Applied Bio Materials· 0 citations
In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.