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Review Open access Aug 2026

Research progress and application prospects of multi-omics integration strategies in precision risk stratification of type 1 diabetes mellitus

Type 1 diabetes (T1D) is a chronic metabolic disease mediated by autoimmunity. Its pathogenesis involves complex interactions between genetic susceptibility and environmental factors. Conventional T1D risk stratification primarily relies on genetic markers, islet autoantibodies, and glycemic indicators. Although these...

Zi-Yi Chen, Wen-Tao Liu, Zheng Guo et al. · 0 citations
Aug 2026

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery.

A dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of β cell-specific targeting ligands to enable selective gene delivery to pancreatic β cells is developed and establishes a versatile platform for RNA therapeutics and gene-editing applications in...

Di Yu, Yining Zhu, A. Roca-Rivada et al. · 1 citation

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