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Author

Zheng-Ming Shi

2 papers indexed here

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Sep 2026

De Novo Design of Targeted Drugs by Precisely Programming Multiple Molecular Binding

Targeted drug discovery has enabled the development of effective therapies for many diseases. However, a fundamental challenge remains in translating molecular binding into functional performance for the development of novel targeted drugs. Here, we present a programmable DNA nanoframe (NF) strategy that converts lig...

Chuang-Yuan Zhao, Yu Jin, Xue Li et al. · 0 citations
Open access Sep 2026

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

Abstract Polypoidal choroidal vasculopathy (PCV) is a distinct variant of neovascular age‐related macular degeneration (AMD) and a major cause of vision loss in older adults, yet its pathogenesis remains poorly understood. Pachychoroid PCV is a subtype characterized by poor treatment response, minimal typical AMD featu...

Xin-Yu Zhao, Tian-Tian Cheng, Wen-Fei Zhang et al. · 0 citations

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