Author

Zheng Yang

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Aug 2026

Discovery of novel Quinazoline-chalcone hybrids as dual VEGFR-2/P-gp inhibitors to reverse cisplatin resistance in cervical Cancer.

Mechanistic studies revealed that co-administration of 5n significantly restored HeLa/DDP cell sensitivity to cisplatin, reducing the RI of cisplatin from 6.07 to 1.49, outperforming the classical inhibitor, verapamil.

Tong Yan, Mutewaer Muhebuli, M. Ablise et al. · Bioorganic chemistry (Print) · 0 citations