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Zhenkun Dong

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Aug 2026

Targeted Degradation of ATP7B via a Novel Autophagy-Targeting Chimera Promotes Cuproptosis to Potentiate Anti-Tumor Immunity in Clear Cell Renal Cell Carcinoma.

The RNF186-p62-ATP7B axis is identified as a critical regulator of copper homeostasis in ccRCC and Targeting ATP7B via ATAUTAC offers a potent strategy to induce cuproptosis and sensitize ccRCC to immunotherapy.

Muyang Cao, Zhenkun Dong, Yang-Yang Xu et al. · 0 citations

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