Open access
Oct 2026
Integrated spatial and single-cell transcriptomics uncover IFI6⁺ regulatory T-cells and SPP1⁺ macrophages immunosuppressive niches in colorectal cancer.
BACKGROUND In colorectal cancer (CRC), tumor-immune interactions are critical drivers of tumorigenesis, immune evasion, and therapeutic response. Therefore, a deeper spatially resolved understanding of these interactions is urgently needed. METHODS Spatial transcriptomics (ST) of CRC and matched normal samples was us...
Dominika Miroszewska, Shi-Yang Song, Víctor Urbiola-Salvador et al.
· British Journal of Cancer · 0 citations