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Author

Zhi Cheng

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2 papers indexed here

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Open access Aug 2026

A regulatory network underlying idiopathic pulmonary fibrosis

Background Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which genetic susceptibility interacts with epithelial, immune, and mesenchymal remodeling. Although the chromosome 11p15.5 locus contains established IPF susceptibility signals near MUC5B and TOLLIP, the broader regulatory arc...

Gang-Gang Li, Xiaochuan Pan, Yuanyuan Wang et al. · 0 citations
Open access Aug 2026

Multi-omics integration identifies APOE as a metabolic regulator of macrophage-fibroblast crosstalk in idiopathic pulmonary fibrosis

A two-sample Mendelian randomization analysis indicated that genetic liability to AD is associated with a lower risk of developing IPF, and APOE functions as a vital metabolic barrier against pro-fibrotic macrophage polarization in the lung.

Bing Bai, Le Chang, Zhi Cheng et al. · 0 citations

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