Open access
Oct 2026
Hyodeoxycholic acid rejuvenates BMSCs against postmenopausal osteoporosis by attenuating senescence and aberrant adipogenesis via TGR5-ESR1-mediated mitophagy.
HDRCA supplementation alleviates BMSC senescence and aberrant adipogenesis through the TGR5-ESR1-mitophagy axis, providing a basis for the development of endogenous metabolite-based, non-hormonal strategies for PMOP.
Chen-Ying Zeng, Wen-Hui Yu, Yun-Ze Kang et al.
· Journal of Advanced Research · 0 citations