Author

Zhifa Shen

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Oct 2026

Turning DNAzyme into a Stitch-to-Activate Biosensor for Single-Base-Resolution Molecular Diagnostics

The catalytic core of DNAzymes is highly sensitive to local structural perturbations. Conventional DNAzyme-based SNV sensing mainly relies on differences in hybridization stability between matched and mismatched targets. Here, we position the SNV immediately adjacent to the catalytic-core reconstitution junction of a...

Xiang-Ran Wang, Xin-Xin Lu, Zheng-Quan Yang et al. · Analytical Chemistry · 0 citations

Sep 2026

Dual-tetrahedral DNA-enabled strand displacement amplification biosensor for cell imaging and clinical detection of miR-34a-5p in NAFLD.

Xiao-Yan Dai, Mu-Ling Ye, Xiao-Ling Li et al. · Analytical and Bioanalytical... · 0 citations

Open access Jul 2026

Membrane-anchored DNA nanodevice with allosteric aptamer arms enables parallel probing and on-site drug delivery

A DNA nanodevice that anchors to cell membranes and releases chemotherapy only when three specific cancer markers are detected simultaneously is developed, establishing a versatile platform for logic‑controlled, multimarker‑guided cancer theranostics.

Meiqin Zhang, Ying-Sheng Cheng, Nan Chen et al. · Nature Communications · 0 citations