Author

Zhi-Gang Li

2 papers indexed here

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Open access Sep 2026

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

ABSTRACT Hyperuricemia is a major driver of chronic kidney disease, yet the underlying intrarenal mechanisms remain unclear. Here, we establish a genetically defined, multi‐hit mouse model that recapitulates the sustained hyperuricemia, metabolic dysregulation, and progressive fibrosis of human disease. Using this mode...

Yun-Fei Qi, Qiang Zhao, Lve Yue et al. · Advancement of science · 0 citations

Aug 2026

Hepatocyte hnRNPK preserves mitochondrial integrity to restrain liver injury and fibrosis.

BACKGROUND AIMS Liver fibrosis is a global health issue with unclear unified drivers. The RNA-binding protein hnRNPK is critical for hepatic homeostasis, but its role in chronic fibrosis remains undefined. This study investigated hnRNPK-mediated splicing dysregulation in liver fibrosis and its therapeutic potential....

Qian Peng, Sujuan Wang, Yufeng Zhang et al. · Hepatology · 0 citations