Black carp DDX3b suppresses antiviral immunity by inhibiting IRF7 modifications and promoting its lysosomal degradation.
Type I interferons (IFNs) serve as pivotal functional molecules in the antiviral immune response of fish, and their signaling pathways require precise negative regulation to avoid tissue damage caused by excessive immune activation. In the present study, DEAD-box RNA helicase 3b (DDX3b), an ATP-dependent RNA helicase i...