Author

Zhi-Hong Zhang

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Open access Aug 2026

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

A NEK2-AURKA-IFT88 pathway that promotes ubiquitin-dependent IFT88 degradation and cilia loss in basal MIBC models is identified, providing a preclinical basis for further testing of NEK2 targeting in cilia-deficient basal MIBC.

E. Du, Wei Wang, Qiang Su et al. · Cell Death & Disease · 0 citations