IL7R mRNA therapy enhances antitumor T cell immunity and suppresses tumor growth in preclinical tumor models
Abstract Background Interleukin-7 receptor (IL7R) signaling is critical for T-cell survival, homeostasis, and immune function, but the therapeutic potential of increasing IL7R expression through messenger RNA (mRNA) delivery remains poorly defined. We investigated whether IL7R mRNA therapy could enhance antitumor immun...