Author

Zhi-Hui Cheng

3 papers indexed here

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Open access Aug 2026

Ehrlichia chaffeensis DapE Is Essential for Intracellular Growth and Represents a Promising Therapeutic Target

Ehrlichia chaffeensis is an obligate intracellular bacterium that proliferates within monocytes or macrophages and causes human monocytic ehrlichiosis (HME), an emerging life-threatening zoonosis. Doxycycline is the choice of treatment for HME, yet it has prominent side effects. Host cells lack the lysine biosynthetic...

Meng-Yao Wang, Yu-Hong Zhou, Meng-Xiao Li et al. · Microorganisms · 0 citations

Open access Sep 2026

Dequalinium chloride promotes the killing efficacy of aminoglycoside antibiotics against Pseudomonas aeruginosa by enhancing membrane potential

ABSTRACT Dequalinium chloride is a dicationic amphiphilic quaternary ammonium compound that is used as an anti-infective drug. Here, we found that it potentiates bactericidal efficacies of aminoglycoside antibiotics against Pseudomonas aeruginosa. Dequalinium chloride increases respiratory activity and bacterial membra...

Xiao-Ya Wei, Zhong-Hui Yang, Yu-Jie Zhang et al. · Microbiology spectrum · 0 citations

Open access Jul 2026

Pst and Tat Systems Are Essential for Ehrlichia chaffeensis Intracellular Survival and Regulated by CtrA

Ehrlichia chaffeensis is an obligate intracellular Gram-negative bacterium that infects human monocytes and macrophages, causing human monocytic ehrlichiosis (HME). HME is an emerging and highly threatening tick-borne infectious disease. CtrA functions as the response regulator of the CckA/CtrA two-component regulatory...

Yuhong Zhou, Meng-Yao Wang, Yi-Xian Qiu et al. · Microorganisms · 0 citations