Author

Zhihui Wang

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Open access Oct 2026

Integrating ferroptosis and the tumor-immune gene mutations interface: a novel lenvatinib resistance prognostic signature with YWHAB-related immunotherapeutic correlates in hepatocellular carcinoma

Lenvatinib resistance represents a major clinical challenge in the treatment of hepatocellular carcinoma (HCC), necessitating the identification of strategies to overcome this issue. Although ferroptosis, a non-apoptotic cell death process, is implicated in the progression of HCC and the response to lenvatinib, the...

Hang Yu, Zhi-Hui Wang, Hong-Liang Zou et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

TRIM27-Cas9-loaded EVs suppress HCC proliferation and enhance responsiveness to anti-PD-1 therapy by promoting ACSL4-mediated ferroptosis.

It is suggested that TRIM27 confers ferroptosis resistance via facilitating K48-linked ubiquitination and subsequent proteasomal degradation of ACSL4 and developed TRIM27-Cas9-loaded EVs with robust editing efficiency.

Jie Wen, Zhihui Wang, Zhirui Zeng et al. · Cell Death and Differentiati... · 1 citation