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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Zhijian Huang

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Review Open access Nov 2026

Machine learning for RNA–small molecule interactions: methodologies, evaluation, and future directions

Abstract RNA is emerging as a compelling therapeutic target due to its rich structural diversity and central involvement in gene regulation, splicing, translation, and cellular signaling. Alongside advances in structural biology, computational approaches, especially machine learning and deep learning, have transformed...

Song Chen, Zhi-Jian Huang, Yu-Cheng Wang et al. · 0 citations
Open access Aug 2026

Pocket-PROTACs: an interpretable pocket-aware deep learning framework for predicting PROTAC-induced protein degradation

Pocket-PROTACs is proposed, a pocket-aware attention-based framework for predicting PROTAC-induced protein degradation from a triplet of POI, E3 ligase, and PROTAC, which consistently outperforms fingerprint-based baselines and recent deep learning methods.

Kai Chen, Zhijian Huang, Yinbo Wang et al. · 0 citations

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