Unraveling shared immunotoxicological mechanisms linking exposure to PPCPs with Alzheimer's disease and atherosclerosis: integrative multi-omics, network toxicology, and experimental validation.
BACKGROUND Pharmaceuticals and personal care products (PPCPs) are pseudo-persistent contaminants with potential exposure risks. Atherosclerosis (AS) and Alzheimer's disease (AD) share neurovascular and myeloid-immune remodeling, but whether chemical-target networks associated with exposure to PPCPs converge on shared m...