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Open access Jul 2026

ZC3H13‐mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti‐PD‐1 response in HNSCC

Abstract Background Resistance to immune checkpoint blockade substantially limits its clinical efficacy in head and neck squamous cell carcinoma(HNSCC). ZC3H13 is a component of the N6‐methyladenosine writer complex, but its roles in HNSCC progression and response to anti‐programmed cell death protein 1(anti‐PD‐1) ther...

Wen-Qing Chen, Yun Li, Shuang Chen et al. · 0 citations
Open access Jul 2026

Single-cell and spatial transcriptomic analysis reveal distinct tumor microenvironment signatures in primary and recurrent hypopharyngeal squamous cell carcinoma.

BACKGROUND Hypopharyngeal squamous cell carcinoma (HPSCC) is a rare, highly aggressive malignancy, with recurrence playing a pivotal role in treatment failure and cancer-related mortality. The tumor microenvironment (TME) characteristics and molecular mechanisms driving recurrence in HPSCC remain poorly defined. MATE...

Z. Cai, Jinhong Zhang, Yaodong Ding et al. · 0 citations

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