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Author

Zhi-Min Shao

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4 papers indexed here

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Open access Sep 2026

Integrated analysis reveals the impact of obesity on triple-negative breast cancer.

It is revealed that obesity is associated with coordinated immune-metabolic remodeling in TNBC, characterized by checkpoint enrichment and lipid dysregulation, which may help explain the enhanced anti-PD-1 responsiveness and should be taken into account in the field of precision medicine.

P. Ji, Huai-Liang Wu, Li-Huan He et al. · 0 citations
Open access Oct 2026

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

A previously unrecognized VCP‐LMF2‐HMGCS1 regulatory axis that drives TNBC progression and chemoresistance is unveiled, and lipase maturation factor 2 is identified as a promising therapeutic target for this recalcitrant disease.

Qian Zhao, Lisa Andriani, Yin-Ling Zhang et al. · 0 citations
Open access Aug 2026

Decoding age-stratified clinical and molecular heterogeneity in male breast cancer through multiomic profiling.

Objective Age-associated molecular heterogeneity is well described in female breast cancer but remains insufficiently characterized in male breast cancer (MBC). We profiled age-stratified clinical and molecular differences between younger (≤55 years) male breast cancer (YMBC) and older (>55 years) male breast cancer (O...

Zhi-Shuang Gao, Ze-Hao Wang, Yue Zhou et al. · 0 citations

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