Author

Zhi-Ping Weng

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Open access Oct 2026

Inferring binding specificities of human transcription factors with the wisdom of crowds.

DNA motif discovery and, particularly, computational modeling of transcription factor binding motifs, has been a mecca of algorithmic bioinformatics for several decades. Here, we report the results of the largest open community challenge in Inferring BInding Specificities (IBIS), where participants all over the world w...

Nikita Gryzunov, Dmitry D. Penzar, V. Kamenets et al. · Cell Reports · 0 citations

Review Sep 2026

Genome-wide survey of spliceosomal snRNA transcripts across hundreds of human biosamples reveals abundant transcription but low maturation level of snRNA variants.

Small nuclear RNAs (snRNAs) are essential components of the spliceosome and are encoded by large, multicopy gene families. However, their genome-wide identification and quantification have remained challenging due to high sequence similarity among family members. To address this, we utilized RAMPAGE (Rapid Amplificatio...

Xiao-Ou Zhang, Ya Zhang, Zhi-Ping Weng · Genome Research · 0 citations

Open access Jul 2026

An encyclopedia of human enhancer–gene regulatory interactions

An encyclopedia of enhancer–gene regulatory interactions in the human genome is built, revealing global properties of enhancer networks, identifying differences in regulatory complexity across genes, and improving analyses linking noncoding variants to target genes and cell types for common, complex diseases.

A. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh et al. · Nature · 6 citations