Biomimetic platelet membrane-camouflaged nanomicelles for synergistic hypoxia alleviation and immune activation to potentiate immunotherapy in TNBC.
Triple-negative breast cancer (TNBC) remains poor response to immunotherapy, largely attributable to the hypoxic tumor microenvironment that drives functional exhaustion of effector T cells and natural killer (NK) cells. To counter this, we engineered platelet-membrane-biomimetic nanomicelles (PM@(M/B)NM) for the co-de...