Author

Zhi-Qiang Song

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Sep 2026

A bioactive hydrogel regulates chondrocyte fate with hypoxia-mimetic chondrogenic induction and vascular invasion suppression for full-thickness cartilage repair.

Chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is always compromised by hypertrophic maturation, rendering long-term phenotype maintenance a key challenge. While hypoxia drives chondrogenic commitment, sustained hypoxic stimulation within the injured joint paradoxically accelerates hypertrop...

Jia-Hui Liang, Hui-Chun Yan, Xue-Miao Liu et al. · Biomaterials · 0 citations

Open access Aug 2026

A Self‐Adaptive Programming Strategy Enables Local Microenvironment Modulation and Temporal Immunomodulation for Diabetic Infected Bone Regeneration

Both in vitro and in vivo studies confirm that PEG‐ZnO‐sita effectively promotes bone regeneration by local hyperglycemic microenvironment modulation and sequential regulation of macrophage polarization, presenting a promising strategy for diabetic infected bone defects.

Xiaoyang Ding, Zhi-Qiang Song, Jing Li et al. · Advanced Healthcare Material... · 0 citations