Zhi-Tao Shangguan

Prodh2‐Mediated Mitochondrial Stress Drives TNF‐α‐Induced Myoblast Dysfunction and Sarcopenia in COPD

ABSTRACT Sarcopenia in chronic obstructive pulmonary disease (COPD) is driven by elevated tumor necrosis factor‐alpha (TNF‐α), yet the underlying mechanism remains unclear. Here, we identify the mitochondrial metabolic enzyme Prodh2 as a pivotal mediator. Prodh2 was significantly upregulated in sarcopenic COPD patients...