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Zhi-Wen Zhu

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Open access Sep 2026

Spatially Confined Phase Separation Promotes Local Tubulin Availability to Stabilize Ciliary Microtubule Growth

How microtubule (MT) growth is locally sustained within cilia remains a central unanswered question in ciliogenesis. Here we identify RAT-1 as a regulator of ciliary tubulin homeostasis and MT growth. Genetic screens in Caenorhabditis elegans show that loss of RAT-1 suppresses the toxic effects of a mutant α-tubulin an...

Kai-Ming Xu, Zhi-Wen Zhu, Yongping Chai et al. · 0 citations

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