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Zhi-Xia Chi

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Open access Sep 2026

Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment

It is demonstrated that the unique P4I interface is a promising therapeutic target and that etravirine serves as a proof-of-concept lead compound for exploring the potential of P4I-targeted strategies in prostate cancer.

Zhi-Xia Chi, Xue-Yong Xu, Zhi-Hang Shen et al. · 0 citations

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