Zhi-Xia Qiu

Discovery and Optimization of Indole-Based CDK9 Inhibitors for Hepatocellular Carcinoma

CDK9 has emerged as a promising therapeutic target for anticancer drug development. Although multiple CDK9 inhibitors have entered clinical evaluation, differentiated scaffolds with convincing activity and tolerability in solid tumors remain limited. In this study, we identified a series of indole-based CDK9 inhibito...