Author

Zhi-Xiong Yang

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Clinical trial Open access Aug 2026

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR-activating mutations. In this phase III, randomized, double-blind trial in China, 336 eligible patients...

Jia Yu, Anwen Xiong, Qi-Ming Wang et al. · Signal Transduction and Targ... · 0 citations

Sep 2026

Identification of Causal Plasma Proteins and Immune Mediators for Lung Cancer in Never-Smokers: A Large-Scale Integrative Analysis Combining Mendelian Randomization, Colocalization, and Mediation.

OBJECTIVE As global smoking rates decline, Lung Cancer in Never-Smokers (LCINS) has emerged as a distinct and increasingly important clinical entity. However, its underlying pathogenesis remains poorly understood, highlighting the need to identify circulating molecular determinants and candidate biomarkers. METHODS G...

Jian-Cong Wu, Qi Zhang, Yan-Ming Lin et al. · Current Medicinal Chemistry · 0 citations