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Review Open access Jul 2026

The endo-lysosomal–lipid axis: bidirectional interactions between membrane trafficking dysfunction and lipid metabolic disorders

The reciprocal interactions between lipid metabolism and endo-lysosomal function are summarized, with particular emphasis on membrane trafficking, lysosomal homeostasis, autophagy, membrane contact sites, and multicellular lipid clearance networks.

Yao Du, Li Li, Mingtao Du et al. · 0 citations
Review Jul 2026

Immune cell metabolic reprogramming mediates ICI therapy resistance.

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced malignancies; however, their efficacy in solid tumors remains limited by therapy resistance. This resistance arises from the metabolic reprogramming of immune cells in the tumor microenvironment (TME), a metabolic 'cage' where immune and...

Zhi Xu, Kequan Xu, Yi Ju et al. · 0 citations

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