Author

Zhiyuan Chen

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Open access Sep 2026

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

Precise temporal control of gene expression is fundamental for embryonic development, yet the epigenetic and chromatin basis governing transcriptional timing remain poorly understood. The bivalency model, characterized by coexistence of H3K4me3 and H3K27me3, has been proposed to mark a poised state ready for activation...

Cheng-Jie Zhou, Meng Wang, Zhi-Yuan Chen et al. · bioRxiv · 0 citations

Open access Aug 2026

YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes

It is shown that microtubule expression and network density decline with cardiac maturation, which identifies microtubule networks as an essential regulator modulating CM dedifferentiation and sarcomere reorganization, which is critical for CM cytokinesis and cardiac regenerative repair.

Feng Zhang, Jenna Cusick, Jie Liang et al. · Circulation · 1 citation