Two PSEN1 E280A carriers have presented extreme protection against autosomal dominant Alzheimer’s disease (ADAD), with over two decades of delay for dementia onset. One of them, a male heterozygous for the RELN-COLBOS protective variant showed increased neuronal density in the entorhinal cortex 1. We conducted a deep p...
Yassir El-Amri, N. Villalba-Moreno, Julia A. Urban et al.· bioRxiv· 0 citations
Protein–Protein Interactions (PPIs) are fundamental to cellular processes and represent major targets for therapeutic development. Recent advances in machine learning for protein modeling, particularly protein language models, have enabled powerful representations of protein sequences and monomeric structures. However,...
Zhi-Yuan Song, Zi-Yu Shi, Gary Sun et al.· bioRxiv· 0 citations
Alzheimer's disease progresses heterogeneously across diverse cohorts, yet current predictive models fail to capture this complexity while remaining clinically interpretable. Here we present a multi-dimensional attention framework that simultaneously captures both temporal dynamics and biomarker importance to predict d...
Zhi-Yuan Song, Si-Yang Song, Isabel C. H. Clare et al.· Research Square· 0 citations
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