Author

Zhi-Yun Yang

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Review Open access Sep 2026

Soluble CTLA-4 as a context-dependent immune checkpoint: biology, biomarker potential, and therapeutic implications

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) exists not only as a membrane-bound immune checkpoint but also as a naturally secreted soluble isoform (sCTLA-4), generated primarily through exon 3 skipping. This review focuses specifically on splice-derived sCTLA-4 and examines its biological and clinical signific...

Xue Cai, Li-Hua Yu, Xiao-Li Liu et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Prognostic value of different sarcopenia assessment methods for mortality in patients with liver cirrhosis: a systematic review and meta-analysis

Background and Aims Sarcopenia is common among patients with cirrhosis and is closely associated with poor prognosis. However, the value of different methods for assessing sarcopenia in predicting mortality risk in patients with cirrhosis remains controversial. This study aims to systematically evaluate the predictive...

Wen-Rui Xie, Wan-Xin Shi, Run-Bing Xu et al. · Frontiers in Nutrition · 0 citations