Author

Zhi Zheng

3 papers indexed here

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Open access Aug 2026

Asexual Development and Virulence Are Not Affected by Knockout of Five Sexual-Stage Candidate Genes in Toxoplasma gondii

Simple Summary Toxoplasma gondii is a common parasite that infects humans and nearly all birds and mammals, posing a serious threat to immunocompromised individuals and pregnant women, and causing significant economic losses to the livestock industry. Its sexual reproduction occurs exclusively in cat intestines, a poor...

Xing Tian, Cheng Tian, Xin-Sheng Lu et al. · Animals · 0 citations

Open access Sep 2026

Toxoplasma gondii infection disrupts secondary bile acid transformation in feline gut microbiota

ABSTRACT Bile acid (BA) transformation relies on gut microbiota and is vulnerable to Toxoplasma gondii infection, yet feline microbial BA-transforming capacity upon toxoplasmosis remains unclear. Here, we constructed a catalog of 2,474 nonredundant feline gut microbial genomes and integrated serum metabolomic data to v...

Lu-Yao Tang, He Zhang, Ji-Xin Zhao et al. · Applied and Environmental Mi... · 0 citations

Open access Aug 2026

A Live Attenuated AP2X-1-Deficient Toxoplasma Strain Confers Protective Immunity Against Acute and Chronic Toxoplasmosis in a Murine Model

PruΔap2X-1 represents a potential live-attenuated vaccine candidate against toxoplasmosis, with a favorable safety profile observed under the experimental conditions, and induces a strong Th1-biased cellular and humoral immune response.

Wen-Bo Hao, Li-Xiu Sun, Ru-Shi Tu et al. · Animals · 0 citations