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Author

Zhifeng Gu

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2 papers indexed here

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Aug 2026

JOSD2 attenuates the aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis by deubiquitinating and stabilizing ZNF148.

BACKGROUND Activated fibroblast-like synoviocytes (FLS) significantly promote synovial inflammation and bone destruction in rheumatoid arthritis (RA). Emerging evidence illustrates that ubiquitination significantly drives both inflammatory processes and the regulation of immunity. This study aimed to elucidate the role...

Teng Wu, Qingshui Wen, Yu-Nan Wang et al. · 0 citations
Jul 2026

Calycosin triggers ferroptosis through modulation of the OTUD6B/GPX4 axis to suppress triple-negative breast cancer.

BACKGROUND Triple-negative breast cancer (TNBC) is a clinically challenging disease subtype of breast cancer, with therapeutic outcomes remaining unsatisfactory due to its highly invasive potential. Ferroptosis, a newly identified type of programmed cell death, is mediated by the iron-dependent accumulation of lipid pe...

Xue Mao, Yin Lin, Zhifeng Gu et al. · 0 citations

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