GPLD1-mediated regulation of the type I interferon-induced signaling pathway and antiviral activity.
Glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) is traditionally known as a secreted enzyme that sheds glycosylphosphatidylinositol (GPI)-anchored proteins. Emerging evidence suggests its involvement in immune modulation. In this study, we report a non-canonical intracellular function of GPLD1 in potenti...