Author

Zhiwei Chen

2 papers indexed here

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Jul 2026

Spatially Driven DNA-Based Probe Proximity Assay for Total Antibody Quantification in Antibody-Drug Conjugates.

This method reduces the recovery loss caused by decreased affinity from payload conjugation and delivers comparable signals for trastuzumab, T-DM1, and T-DXd, which provides a novel approach to address accuracy issues arising from affinity changes due to ADC dynamics in vivo.

Zhiwei Chen, Yu-Ling Liao, Ying Zhou et al. · ACS Sensors · 0 citations

Aug 2026

Super-antifouling electrochemical biosensor based on a biomimetic gemini zwitterionic interface for sensitive detection of therapeutic antibodies.

Biofouling, arising from the nonspecific adsorption of proteins, cells, and other biomolecules, remains a major challenge that compromises the stability and reliability of diagnostic and therapeutic platforms. To address this issue, a super-antifouling electrochemical aptasensor was developed by integrating a biomimeti...

Zheng Zhao, Wan-Qing Yu, Haidong Li et al. · Bioelectrochemistry · 0 citations